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[Epicardial adiposity as risk factor of coronary atherosclerosis].
- Source :
-
Kardiologiia [Kardiologiia] 2013; Vol. 53 (1), pp. 51-6. - Publication Year :
- 2013
-
Abstract
- Aim: To study effect of epicardial adiposity on risk of development and severity of coronary atherosclerosis.<br />Material and Methods: We registered classical metabolic risk factors (RF) and additional factors of cardiovascular risk in 138 men aged 55.47+/-9.07 years with ischemic heart disease (IHD), functional class (FC) II-III angina, and I-III degree obesity. Diagnostic coronary angiography (CAG) was performed in all patients. Thickness of epicardial fat (tEF) in millimeters was measured at transthoracic echocardiography (ECG).<br />Results: Average tEF indexes were highest (10 [8; 10] mm) in the group of patients with multiple stenoses in coronary arteries (CA). According to ROC-analysis tEF appeared to be a predictor of significant coronary atherosclerosis. Its sensitivity was 80.4%, specificity - 67.6 % (cut-off value 6 mm). Epicardial adiposity was among factors associated with presence of coronary atherosclerosis (odds ratio [OR] 4.44, 95% confidence interval [CI] 2,06 to 9.59; p<0,001) along with age (OR 6.56; 95% CI 2.59 to 16.60; p=0,001), leptin (OR 3.50; 95% CI 1.46 to 8.37; p <0,001), resistin (OR 3.13; 95% CI 1.32 to 7.42; p <0,001) and waist circumference (OR 1.65; 95% CI 0.72 to 3.80; p=0.018).
- Subjects :
- Age Factors
Coronary Angiography
Coronary Artery Disease blood
Coronary Artery Disease complications
Coronary Artery Disease physiopathology
Coronary Vessels physiopathology
Humans
Lipids blood
Male
Middle Aged
Obesity blood
Obesity complications
Obesity physiopathology
Odds Ratio
Predictive Value of Tests
ROC Curve
Risk Factors
Waist Circumference
Adiposity
Coronary Artery Disease diagnosis
Echocardiography methods
Obesity diagnosis
Pericardium diagnostic imaging
Pericardium pathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0022-9040
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Kardiologiia
- Publication Type :
- Academic Journal
- Accession number :
- 23548351