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The evaluation and management of drug effects on cardiac conduction (PR and QRS intervals) in clinical development.
- Source :
-
American heart journal [Am Heart J] 2013 Apr; Vol. 165 (4), pp. 489-500. Date of Electronic Publication: 2013 Feb 21. - Publication Year :
- 2013
-
Abstract
- Recent advances in electrocardiographic monitoring and waveform analysis have significantly improved the ability to detect drug-induced changes in cardiac repolarization manifested as changes in the QT/corrected QT interval. These advances have also improved the ability to detect drug-induced changes in cardiac conduction. This White Paper summarizes current opinion, reached by consensus among experts at the Cardiac Safety Research Consortium, on the assessment of electrocardiogram-based safety measurements of the PR and QRS intervals, representing atrioventricular and ventricular conduction, respectively, during drug development.<br /> (Copyright © 2013 Mosby, Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-6744
- Volume :
- 165
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 23537964
- Full Text :
- https://doi.org/10.1016/j.ahj.2013.01.011