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Thrombotic and cardiovascular complications related to nonionic contrast media during cardiac catheterization: analysis of 8,517 patients.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1990 Jun 15; Vol. 65 (22), pp. 1481-4. - Publication Year :
- 1990
-
Abstract
- The incidence of major complications associated with nonionic contrast media has not been defined in a large study. Accordingly, cardiovascular complications, especially thrombotic events, were prospectively evaluated in 8,517 consecutive patients undergoing diagnostic cardiac catheterization with either iopamidol (n = 6,293) or iohexol (n = 2,224). Thrombotic events were defined as coronary embolus, coronary occlusion, transient ischemic attack or stroke occurring at the time of catheterization. Thrombotic events occurred in 15 patients (0.18%). Coronary thrombus or embolus occurred in 7 patients, a thromboembolus from the ventricular catheter occurred in 1 patients and transient ischemic attack or stroke occurred in 7 patients. Six of 15 patients with thrombotic events were premedicated with heparin. Thrombotic events were unusual in that they tended to occur in clusters within short time intervals. On 1 occasion, a thrombus was observed in the catheter tip before embolization. Other cardiovascular complications were similarly low with an incidence of ventricular tachycardia/fibrillation of 0.1%, profound bradycardia of 0.2% and prolonged angina of 0.3%. There were 2 deaths unrelated to thrombotic events. Although the clinical thrombotic events associated with nonionic contrast have an unusual temporal clustering and may result in major complications, the overall incidence (0.18%) of these thrombotic complications with nonionic contrast agents is quite similar to that reported with ionic contrast media.
- Subjects :
- Aged
Cardiovascular Diseases etiology
Cerebrovascular Disorders chemically induced
Cerebrovascular Disorders etiology
Embolism chemically induced
Embolism etiology
Female
Humans
Male
Middle Aged
Prospective Studies
Thrombosis chemically induced
Thrombosis etiology
Cardiac Catheterization adverse effects
Cardiovascular Diseases chemically induced
Iohexol adverse effects
Iopamidol adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 65
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 2353655
- Full Text :
- https://doi.org/10.1016/0002-9149(90)91359-e