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Anticoagulant effect of inositol hexasulfate as measurable by clotting times of fibrinogen and recalcified plasma.
- Source :
-
Thrombosis research [Thromb Res] 1990 May 01; Vol. 58 (3), pp. 243-50. - Publication Year :
- 1990
-
Abstract
- Thrombin-clotting time of fibrinogen was delayed by inositol hexasulfate (IHS). Clotting time of the recalcified plasma was also delayed by IHS. Moreover, when IHS was intravenously injected into anesthetized male rabbits (0.11 mmoles/kg), it delayed clotting time of the recalcified plasma. IHS prevented generations of factor Xa and thrombin in the recalcified plasma. It is probable that IHS inhibits the clot-formation of the recalcified plasma in competition with calcium ions.
- Subjects :
- Amino Acid Sequence
Animals
Blood Coagulation Tests
Cattle
Factor Xa biosynthesis
Injections, Intravenous
Inositol pharmacology
Male
Molecular Sequence Data
Rabbits
Thrombin drug effects
Anticoagulants
Calcium antagonists & inhibitors
Fibrinogen drug effects
Inositol analogs & derivatives
Plasma drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0049-3848
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 2353338
- Full Text :
- https://doi.org/10.1016/0049-3848(90)90094-s