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Pediatric glioblastoma with oligodendroglioma component: aggressive clinical phenotype with distinct molecular characteristics.
- Source :
-
Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2013 Dec; Vol. 33 (6), pp. 652-7. Date of Electronic Publication: 2013 Mar 27. - Publication Year :
- 2013
-
Abstract
- The 2007 World Health Organization classification defined a new variant of glioblastoma (GBM) containing oligodendroglioma foci as GBM with an oligodendroglioma component (GBMO), which shows a favorable clinical outcome compared with "classic" GBM. However, all of the reported cases of GBMO have been adult cases, with no previous reports of pediatric cases. In this report, we demonstrated molecular characteristics of a pediatric GBMO case, showing aggressive clinical behavior with 8-month overall survival. The case showed neither isocitrate dehydrogenase 1/2 genes (IDH1/2) mutation nor 1p/19q co-deletion, a hallmark of oligodendroglioal tumors. In addition, microsatellite instability, leading to the putative mechanism of temozolomide (TMZ) resistance, was frequently detected. Molecular genetic analysis may provide critical prognostic and therapeutic insights, especially for the pediatric glioma containing oligodendroglioma components.<br /> (© 2013 Japanese Society of Neuropathology.)
- Subjects :
- Brain Neoplasms genetics
Brain Neoplasms therapy
Chemoradiotherapy
Child
Dacarbazine analogs & derivatives
Dacarbazine therapeutic use
Fatal Outcome
Glioblastoma genetics
Glioblastoma therapy
Humans
Male
Microsatellite Instability
Neoplasms, Complex and Mixed genetics
Neoplasms, Complex and Mixed therapy
Neurosurgical Procedures
Oligodendroglioma genetics
Oligodendroglioma therapy
Phenotype
Temozolomide
Brain Neoplasms pathology
Glioblastoma pathology
Neoplasms, Complex and Mixed pathology
Oligodendroglioma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1789
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuropathology : official journal of the Japanese Society of Neuropathology
- Publication Type :
- Academic Journal
- Accession number :
- 23530875
- Full Text :
- https://doi.org/10.1111/neup.12029