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Anti-inflammatory cycloartane-type saponins of Astragalus membranaceus.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2013 Mar 25; Vol. 18 (4), pp. 3725-32. Date of Electronic Publication: 2013 Mar 25. - Publication Year :
- 2013
-
Abstract
- A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Cell Line, Tumor
Cell Survival drug effects
Glycosides analysis
Glycosides chemistry
Inhibitory Concentration 50
Macrophages drug effects
Magnetic Resonance Spectroscopy
Mice
Plant Extracts chemistry
Plant Roots chemistry
Saponins chemistry
Triterpenes analysis
Triterpenes chemistry
Anti-Inflammatory Agents analysis
Astragalus propinquus chemistry
Plant Extracts analysis
Saponins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 23529032
- Full Text :
- https://doi.org/10.3390/molecules18043725