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Does lithium carbonate affect the ion transport abnormality in cystic fibrosis?
- Source :
-
Pediatric pulmonology [Pediatr Pulmonol] 1990; Vol. 8 (2), pp. 82-8. - Publication Year :
- 1990
-
Abstract
- Lithium is known to affect several aspects of cellular regulation which may be related to ion channel function in epithelial cells. To determine whether the ion transport abnormality in cystic fibrosis (CF) is affected by lithium with resultant changes in clinical status, 36 CF patients, 12-37 years old, were enrolled in a 14 week, double-blind, placebo-controlled trial. Eighteen patients were randomly assigned to receive lithium carbonate for 10 weeks. At the end of therapy their average serum lithium concentration was 0.56 +/- 0.06 mmol (SEM) per liter. Their sweat chloride concentration fell from 92.1 +/- 4.8 mmol per liter to 87.4 +/- 4.0 mmol per liter after 10 weeks of therapy (P = 0.07) and rose to 94.4 +/- 3.5 mmol per liter 4 weeks after end of therapy (P less than 0.001 compared to results at end of therapy). Their forced vital capacity (FVC) fell from 72 +/- 5.3% of predicted to 66 +/- 5.1% of predicted after 4 weeks of therapy (P less than 0.01), and their forced expiratory volume in one second (FEV1) fell from 56 +/- 5.5% of predicted to 51 +/- 5.5% of predicted after 4 weeks of therapy (P less than 0.01). In a non-blind assessment, performed 19 weeks after the end of therapy, their FVC and FEV1 had risen and were not significantly different from baseline. Sweat chloride, FVC, and FEV1 remained unchanged in the placebo group throughout the period of study.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adolescent
Adult
Biological Transport drug effects
Child
Cystic Fibrosis metabolism
Double-Blind Method
Drug Evaluation
Female
Forced Expiratory Volume drug effects
Humans
Lithium adverse effects
Male
Sweat analysis
Vital Capacity drug effects
Chlorides metabolism
Cystic Fibrosis drug therapy
Lithium therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 8755-6863
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 2352788
- Full Text :
- https://doi.org/10.1002/ppul.1950080205