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Building a sulfonamide library by eco-friendly flow synthesis.
- Source :
-
ACS combinatorial science [ACS Comb Sci] 2013 May 13; Vol. 15 (5), pp. 235-9. Date of Electronic Publication: 2013 Apr 01. - Publication Year :
- 2013
-
Abstract
- A rapid and eco-friendly synthesis of a sulfonamide library under flow conditions is described. The study illustrates an efficient, safe, and easily scalable preparation of sulfonamides by use of a meso-reactor apparatus, thus demonstrating the impact of flow technologies within drug discovery. Waste minimization, employment of green media, and nontoxic reactants are achieved by the optimization of the flow setup and experimental protocol designed to sequentially synthesize primary, secondary, and tertiary sulfonamides. Isolation of the products involves only extraction and precipitation affording pure compounds in good to high yields without further purification for biological evaluation.
Details
- Language :
- English
- ISSN :
- 2156-8944
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS combinatorial science
- Publication Type :
- Academic Journal
- Accession number :
- 23514257
- Full Text :
- https://doi.org/10.1021/co400012m