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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.

Authors :
Kandioller W
Balsano E
Meier SM
Jungwirth U
Göschl S
Roller A
Jakupec MA
Berger W
Keppler BK
Hartinger CG
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Apr 25; Vol. 49 (32), pp. 3348-50.
Publication Year :
2013

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Details

Language :
English
ISSN :
1364-548X
Volume :
49
Issue :
32
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
23505633
Full Text :
https://doi.org/10.1039/c3cc40432c