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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Apr 25; Vol. 49 (32), pp. 3348-50. - Publication Year :
- 2013
-
Abstract
- Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
- Subjects :
- Amino Acids chemistry
Antineoplastic Agents, Phytogenic chemistry
Cell Line, Tumor
Cell Survival drug effects
Coordination Complexes chemistry
Guanine analogs & derivatives
Guanine chemistry
Humans
Naphthoquinones chemistry
Osmium chemistry
Reactive Oxygen Species metabolism
Rhodium chemistry
Ruthenium chemistry
Antineoplastic Agents, Phytogenic pharmacology
Coordination Complexes pharmacology
Naphthoquinones pharmacology
Osmium pharmacology
Rhodium pharmacology
Ruthenium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 49
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23505633
- Full Text :
- https://doi.org/10.1039/c3cc40432c