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Intradermally-administered influenza virus vaccine is safe and immunogenic in healthy adults 18-64 years of age.
- Source :
-
Vaccine [Vaccine] 2013 May 01; Vol. 31 (19), pp. 2358-65. Date of Electronic Publication: 2013 Mar 13. - Publication Year :
- 2013
-
Abstract
- Background: To increase vaccine acceptance, intradermal (ID) influenza vaccine (Fluzone(®) Intradermal, Sanofi Pasteur Inc.) may be an attractive alternative to intramuscular (IM) vaccination due to smaller needle and volume injected.<br />Methods: A multicenter, randomized (2:1 ID vs IM vaccines) study, blinded for ID vaccine lots, was conducted among 4292 adults 18-64 years of age enrolled in October 2008. Three lots of investigational trivalent influenza vaccine containing 9μg hemagglutinin (HA) per strain in 0.1mL administered ID with a 30 gauge, 1.5mm long needle were compared to standard dose vaccine (0.5mL containing 15μg HA/strain) given IM.<br />Results: The post-vaccination antibody geometric mean titers (GMT) for the ID vaccine were similar to the IM vaccine (H1N1: 193.2 vs. 178.3, H3N2: 246.7 vs. 230.7, and B: 102.5 vs. 126.9). Non-inferiority was met for the ID vaccine compared to IM vaccine as assessed by antibody GMT ratios (IM/ID) for all three virus strains (H1N1: 0.92, H3N2: 0.94, and B: 1.24). Seroconversion rates were non-inferior for H1N1 and H3N2, but not for B (ID vs. IM: H1N1: 61.2% vs. 60.5%, H3N2: 75.3% vs. 74.8%, and B: 46.2% vs. 54.2%). Seroprotection (HAI titer ≥1:40) rates were similar between groups (ID vs. IM, H1N1: 91.1% vs. 91.7%, H3N2: 90.7% vs. 91.4%, and B: 87.4% vs. 89.3%). Local injection site reactions overall were more common with ID than IM vaccine (ID vs. IM: 89.2% vs. 60.2%), but were usually grade 1 or 2 and transient. The frequencies of local injection site pain and systemic reactions were similar between vaccine groups, except more myalgia with IM vaccine.<br />Conclusions: The ID vaccine elicited immune responses comparable to IM vaccine except for the seroconversion rate to B virus. With the exception of pain, local injection site reactions were more common with the ID vaccine, but well-tolerated and of short duration.<br />Trial Registration: ClinicalTrials.gov identifier: NCT00772109.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Antibodies, Viral
Antibody Formation
Double-Blind Method
Female
Hemagglutination Inhibition Tests
Humans
Influenza Vaccines administration & dosage
Influenza Vaccines adverse effects
Injections, Intradermal
Injections, Intramuscular
Male
Middle Aged
Pain
Vaccination
Young Adult
Influenza A Virus, H1N1 Subtype immunology
Influenza A Virus, H3N2 Subtype immunology
Influenza B virus immunology
Influenza Vaccines immunology
Influenza, Human prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 31
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 23499604
- Full Text :
- https://doi.org/10.1016/j.vaccine.2013.03.008