Back to Search
Start Over
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study.
- Source :
-
PloS one [PLoS One] 2013; Vol. 8 (2), pp. e57893. Date of Electronic Publication: 2013 Feb 28. - Publication Year :
- 2013
-
Abstract
- Aims: To examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring hyperthyroidism.<br />Methods and Results: All patients admitted with new-onset AF in Denmark from 1997-2009, and their present and subsequent use of anti-thyroid medication was identified by individual-level linkage of nationwide registries. Patients with previous thyroid diagnosis or thyroid medication use were excluded. Development of hyperthyroidism was assessed as initiation of methimazole or propylthiouracil up to a 13-year period. Risk of hyperthyroidism was analysed by Poisson regression models adjusted for important confounders such as amiodarone treatment. Non-AF individuals from the general population served as reference. A total of 145,623 patients with new-onset AF were included (mean age 66.4 years [SD ±13.2] and 55.3% males) of whom 3% (4,620 events; 62.2% women) developed hyperthyroidism in the post-hospitalization period compared to 1% (48,609 events; 82% women) in the general population (n = 3,866,889). In both women and men we found a significantly increased risk of hyperthyroidism associated with new-onset AF compared to individuals in the general population. The highest risk was found in middle-aged men and was consistently increased throughout the 13-year period of observation. The results were confirmed in a substudy analysis of 527,352 patients who had thyroid screening done.<br />Conclusion: New-onset AF seems to be a predictor of hyperthyroidism. Increased focus on subsequent risk of hyperthyroidism in patients with new-onset AF is warranted.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Cohort Studies
Denmark epidemiology
Drug Prescriptions statistics & numerical data
Female
Hospitalization statistics & numerical data
Humans
Hyperthyroidism diagnosis
Hyperthyroidism drug therapy
Male
Middle Aged
Risk
Young Adult
Atrial Fibrillation complications
Hyperthyroidism complications
Hyperthyroidism epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23469097
- Full Text :
- https://doi.org/10.1371/journal.pone.0057893