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Cesarean section and offspring's risk of multiple sclerosis: a Danish nationwide cohort study.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2013 Oct; Vol. 19 (11), pp. 1473-7. Date of Electronic Publication: 2013 Mar 06. - Publication Year :
- 2013
-
Abstract
- Background: Apart from a recent study reporting a 2- to 3-fold increased risk of multiple sclerosis (MS) among women and men who were delivered by Cesarean section (C-section), little attention has been given to the possible association between mode of delivery and the risk of MS.<br />Objectives: We studied the association between C-section and risk of MS, in a cohort of 1.7 million Danes born from 1973 to 2005.<br />Methods: Information on C-section and MS was obtained from the Danish Medical Birth Register and the Danish MS Register, respectively. The association between C-section and MS was evaluated by means of MS incidence rate ratios (RR) with 95% confidence intervals (CI) obtained in log-linear Poisson regression analyses.<br />Results: There were 930 cases of MS in the study cohort, of whom 80 (9%) were delivered by C-section. Overall, we found there was no significant association between C-section and risk of MS (RR = 1.17; 0.92-1.46). Analyses stratified by sex revealed no unusual risk of MS for women (RR = 1.08: 0.80-1.42) nor men (RR = 1.37: 0.91-1.98). A supplementary sibling-matched Cox regression analysis likewise suggested there was no excess risk of MS in persons delivered by C-section (HR = 1.03; 0.63-1.69).<br />Conclusions: Mode of delivery appears to be unimportant in relation to MS development in the offspring.
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 19
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23466398
- Full Text :
- https://doi.org/10.1177/1352458513480010