Back to Search
Start Over
Prospective study of transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: an Asian cooperative study between Japan and Korea.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2013 Apr; Vol. 24 (4), pp. 490-500. Date of Electronic Publication: 2013 Mar 07. - Publication Year :
- 2013
-
Abstract
- Purpose: To evaluate the safety and efficacy of transcatheter arterial chemoembolization used for the treatment of unresectable hepatocellular carcinoma (HCC) with an Asian cooperative prospective study between Japan and Korea.<br />Materials and Methods: Patients with unresectable HCC unsuitable for curative treatment or with no prior therapy for HCC were enrolled. The patients underwent transcatheter arterial chemoembolization with emulsion of Lipiodol and anthracycline agent, followed by embolization with gelatin sponge particles, which was repeated on an as-needed basis. The primary endpoint was 2-year survival rate, and the secondary endpoints were adverse events and response rate.<br />Results: The 2-year survival rate of 99 patients was 75.0% (95% confidence interval, 65.2%-82.8%). The median time-to-progression was 7.8 months, and the median overall survival period was 3.1 years. Of 99 patients, 42 (42%) achieved a complete response, and 31 (31%) had a partial response. The response rate was 73% using modified Response Evaluation Criteria in Solid Tumors. The grade 3-4 toxicities included increased alanine aminotransferase level in 36%, increased aspartate aminotransferase level in 35%, thrombocytopenia in 12%, and abdominal pain in 4% of patients. All other toxicities were generally transient.<br />Conclusions: Asian transcatheter arterial chemoembolization demonstrated sufficient safety and reasonable efficacy as a standard treatment for unresectable HCC. These results could be useful as reference data for future trials of transcatheter arterial chemoembolization.<br /> (Copyright © 2013 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Anthracyclines adverse effects
Antibiotics, Antineoplastic adverse effects
Carcinoma, Hepatocellular blood supply
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular pathology
Disease Progression
Disease-Free Survival
Ethiodized Oil adverse effects
Female
Gelatin Sponge, Absorbable adverse effects
Humans
Japan
Liver Neoplasms blood supply
Liver Neoplasms mortality
Liver Neoplasms pathology
Male
Middle Aged
Prospective Studies
Republic of Korea
Survival Analysis
Survival Rate
Time Factors
Treatment Outcome
Anthracyclines administration & dosage
Antibiotics, Antineoplastic administration & dosage
Carcinoma, Hepatocellular therapy
Chemoembolization, Therapeutic adverse effects
Chemoembolization, Therapeutic mortality
Ethiodized Oil administration & dosage
Gelatin Sponge, Absorbable therapeutic use
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 23466316
- Full Text :
- https://doi.org/10.1016/j.jvir.2013.01.003