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The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
- Source :
-
Carcinogenesis [Carcinogenesis] 2013 Jul; Vol. 34 (7), pp. 1510-5. Date of Electronic Publication: 2013 Mar 01. - Publication Year :
- 2013
-
Abstract
- The impact of alcohol on the risk of stomach cancer is controversial. Although aldehyde dehydrogenase 2 (ALDH2) Glu504Lys (rs671) polymorphism has a strong effect on acetaldehyde metabolism, little is known about its impact on stomach cancer risk when combined with alcohol drinking. This case-control study included a total of 697 incident stomach cancer case subjects and 1372 non-cancer control subjects who visited Aichi Cancer Center between 2001 and 2005. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ALDH2 genotypes and alcohol consumption using logistic regression models after adjustment for potential confounders, including Helicobacter pylori infection. The ALDH2 504Lys allele was associated with the risk of stomach cancer, with adjusted ORs of 1.40 (95% CI, 1.11-1.76) for Glu/Lys and 1.73 (1.12-2.68) for Lys/Lys compared with Glu/Glu. Heavy drinking was associated with risk (OR 1.72, 1.17-2.52) after adjustment for ALDH2 genotype and other confounders. Moreover, ORs for heavy drinking were 1.28 (0.77-2.12) for those with ALDH2 Glu/Glu and 3.93 (1.99-5.79) for those with the ALDH2 Lys allele relative to non-drinkers with the Glu/Glu genotype (P for interaction = 0.0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis.
- Subjects :
- Acetaldehyde metabolism
Adenocarcinoma genetics
Adenocarcinoma metabolism
Adenocarcinoma pathology
Adult
Aged
Alcohol Drinking genetics
Aldehyde Dehydrogenase genetics
Aldehyde Dehydrogenase, Mitochondrial
Alleles
Case-Control Studies
Confidence Intervals
Female
Genetic Association Studies
Glutathione genetics
Glutathione metabolism
Helicobacter Infections microbiology
Helicobacter pylori pathogenicity
Humans
Logistic Models
Lysine genetics
Lysine metabolism
Male
Middle Aged
Odds Ratio
Risk Factors
Stomach Neoplasms enzymology
Alcohol Drinking adverse effects
Aldehyde Dehydrogenase metabolism
Polymorphism, Genetic
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2180
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 23455379
- Full Text :
- https://doi.org/10.1093/carcin/bgt080