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Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease.
- Source :
-
PloS one [PLoS One] 2013; Vol. 8 (2), pp. e55686. Date of Electronic Publication: 2013 Feb 25. - Publication Year :
- 2013
-
Abstract
- Background: Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional risk factors but appears to be related to increased arterial stiffness. Cytomegalovirus (CMV) infection is associated with increased cardiovascular risk although the mechanisms for this are unknown. We examined whether CMV seropositivity was associated with increased arterial stiffness in patients with chronic kidney disease.<br />Methodology and Principal Findings: In 215 non-diabetic patients with chronic kidney disease, CMV seropositivity was determined using an anti-CMV IgG ELISA. Pulse wave velocity was measured and aortic distensibility assessed in the ascending, proximal descending and distal descending thoracic aorta. Patients seropositive for CMV had a higher pulse wave velocity and lower aortic distensibility at all 3 levels. These differences (except for ascending aortic distensibility) persisted in a subcohort matched for age, gender and renal function, and when the whole cohort was divided into quartiles of age. In multivariable analyses, CMV seropositivity was an independent determinant of pulse wave velocity and proximal and distal descending aortic distensibility.<br />Conclusions: In patients with chronic kidney disease, CMV seropositivity is associated with increased arterial stiffness and decreased distensibility of the proximal descending and distal aorta. These findings suggest that further research is required to examine CMV as a possible cause of arterial disease and increased cardiovascular risk in patients with CKD and may be relevant more widely for CMV seropositive patients with normal renal function.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral blood
Blood Pressure physiology
Cardiovascular Diseases blood
Cardiovascular Diseases etiology
Cardiovascular Diseases virology
Cytomegalovirus immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G blood
Male
Middle Aged
Renal Insufficiency, Chronic blood
Risk Factors
Young Adult
Cytomegalovirus pathogenicity
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic virology
Vascular Stiffness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23451030
- Full Text :
- https://doi.org/10.1371/journal.pone.0055686