A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents.

Authors :: Vasan SK
Fall T
Job V
Gu HF
Ingelsson E
Brismar K
Karpe F
Thomas N
Source :: Pediatric obesity [Pediatr Obes] 2013 Jun; Vol. 8 (3), pp. e45-9. Date of Electronic Publication: 2013 Feb 28.
Publication Year :: 2013
Abstract: Background: Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined. Objective: To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents. Methods: Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India. Results: The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313. Conclusion: The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood. (© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity.)

Subjects :: Adolescent
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Body Mass Index
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
India epidemiology
Male
Obesity ethnology
Phenotype
Waist-Hip Ratio
Diet
Obesity epidemiology
Obesity genetics
Proteins genetics
Receptor, Melanocortin, Type 4 genetics

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