Back to Search
Start Over
Myocyte enhancer factor 2C in hematopoiesis and leukemia.
- Source :
-
Oncogene [Oncogene] 2014 Jan 23; Vol. 33 (4), pp. 403-10. Date of Electronic Publication: 2013 Feb 25. - Publication Year :
- 2014
-
Abstract
- MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.
Details
- Language :
- English
- ISSN :
- 1476-5594
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 23435431
- Full Text :
- https://doi.org/10.1038/onc.2013.56