Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia.

Authors :: Zhang Y
Wang JF
Dong J
Wei JY
Wang YN
Dai XH
Wang X
Luo MJ
Tan W
Deng XM
Niu XD
Source :: Fitoterapia [Fitoterapia] 2013 Apr; Vol. 86, pp. 92-9. Date of Electronic Publication: 2013 Feb 17.
Publication Year :: 2013
Abstract: Staphylococcal pneumonia provoked by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening infection in which α-toxin is an essential virulence factor. In this study, we investigate the influence of naringenin on α-toxin production and further assess its therapeutic performance in the treatment of staphylococcal pneumonia. Remarkably, the expression of α-toxin was significantly inhibited when the organism was treated with 16 μg/ml of naringenin. When studied in a mouse model of S. aureus pneumonia, naringenin could attenuate the symptoms of lung injury and inflammation in infected mice. These results suggest that naringenin is a promising agent for treatment of S. aureus infection.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)

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