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Clinical characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck.
- Source :
-
The Laryngoscope [Laryngoscope] 2013 Jun; Vol. 123 (6), pp. 1430-8. Date of Electronic Publication: 2013 Feb 16. - Publication Year :
- 2013
-
Abstract
- Objectives/hypothesis: This study was intended to evaluate prognostic factors and the role of postoperative radiotherapy (RT) in patients with adenoid cystic carcinoma (ACC) of the head and neck (ACCHN).<br />Study Design: Retrospective study.<br />Methods: Eighty-eight patients with ACCHN who underwent curative intent surgery with or without RT between 1991 and 2009 at a single institute were retrospectively analyzed.<br />Results: Patients with ACC of the sinonasal area (P=.005) and those with diabetes mellitus (DM; P=.027) showed a significantly higher risk of local recurrence. Age (<40 or >60 years, P=.028) and tumor stage III or IV (P=.022) were significant adverse factors predicting distant metastasis. High-grade histology (P=.014) and DM (P=.027) were independently associated with shorter disease-free survival (DFS). In addition, postoperative RT (≥59 Gy) significantly enhanced local control (P=.025) and DFS (P=.001) in both univariate and multivariate analyses.<br />Conclusions: Age, DM, tumor site, histologic grade, and stage were independently significant prognostic factors for ACCHN. In addition, an adequate dose of postoperative radiotherapy can improve local control and DFS of patients with ACCHN.<br /> (Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Adenoid Cystic therapy
Combined Modality Therapy
Disease Progression
Disease-Free Survival
Female
Head and Neck Neoplasms therapy
Humans
Incidence
Male
Middle Aged
Neoplasm Recurrence, Local epidemiology
Prognosis
Republic of Korea epidemiology
Retrospective Studies
Survival Rate trends
Young Adult
Carcinoma, Adenoid Cystic diagnosis
Head and Neck Neoplasms diagnosis
Neoplasm Staging
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 123
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 23417869
- Full Text :
- https://doi.org/10.1002/lary.23976