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Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force.
- Source :
-
The Australian and New Zealand journal of psychiatry [Aust N Z J Psychiatry] 2013 Apr; Vol. 47 (4), pp. 321-32. Date of Electronic Publication: 2013 Feb 14. - Publication Year :
- 2013
-
Abstract
- Although the etiology of bipolar disorder remains uncertain, multiple studies examining neuroimaging, peripheral markers and genetics have provided important insights into the pathophysiologic processes underlying bipolar disorder. Neuroimaging studies have consistently demonstrated loss of gray matter, as well as altered activation of subcortical, anterior temporal and ventral prefrontal regions in response to emotional stimuli in bipolar disorder. Genetics studies have identified several potential candidate genes associated with increased risk for developing bipolar disorder that involve circadian rhythm, neuronal development and calcium metabolism. Notably, several groups have found decreased levels of neurotrophic factors and increased pro-inflammatory cytokines and oxidative stress markers. Together these findings provide the background for the identification of potential biomarkers for vulnerability, disease expression and to help understand the course of illness and treatment response. In other areas of medicine, validated biomarkers now inform clinical decision-making. Although the findings reviewed herein hold promise, further research involving large collaborative studies is needed to validate these potential biomarkers prior to employing them for clinical purposes. Therefore, in this positional paper from the ISBD-BIONET (biomarkers network from the International Society for Bipolar Disorders), we will discuss our view of biomarkers for these three areas: neuroimaging, peripheral measurements and genetics; and conclude the paper with our position for the next steps in the search for biomarkers for bipolar disorder.
- Subjects :
- Biomarkers metabolism
Bipolar Disorder blood
Bipolar Disorder genetics
Bipolar Disorder metabolism
Bipolar Disorder pathology
Humans
Advisory Committees
Bipolar Disorder physiopathology
Brain-Derived Neurotrophic Factor blood
Genetic Predisposition to Disease genetics
Inflammation Mediators blood
Neuroimaging psychology
Oxidative Stress physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1614
- Volume :
- 47
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Australian and New Zealand journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 23411094
- Full Text :
- https://doi.org/10.1177/0004867413478217