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Clinical experience of bendamustine in relapsed or refractory Hodgkin lymphoma: a retrospective analysis of the French compassionate use program in 28 patients.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2013 Nov; Vol. 54 (11), pp. 2399-404. Date of Electronic Publication: 2013 Mar 13. - Publication Year :
- 2013
-
Abstract
- Limited data support the use of bendamustine in Hodgkin lymphoma (HL). This retrospective study evaluated the efficacy and toxicity of bendamustine in 28 patients with refractory HL or relapsed HL after autologous stem cell transplant (ASCT) used as part of a compassionate use program. The median number of therapies before bendamustine was 5 (3-8). ASCT and non-myeloablative allogeneic transplant were previously performed for 25 and six patients, respectively. The median number of bendamustine cycles administered was 3 (1-12). The objective response rate was 50% with complete response (CR) in 29% of patients. The median progression-free survival was 5.7 months, and 10.2 months in patients with CR. During the first six cycles, two patients had a febrile neutropenia and four patients had grade 3-4 thrombocytopenia. Bendamustine was effective in these highly pretreated patients with HL. It might be used earlier in the treatment strategy of HL and in combination with other active drugs.
- Subjects :
- Adult
Aged
Antineoplastic Agents, Alkylating administration & dosage
Antineoplastic Agents, Alkylating adverse effects
Bendamustine Hydrochloride
Compassionate Use Trials
Female
Hodgkin Disease mortality
Hodgkin Disease pathology
Humans
Male
Middle Aged
Neoplasm Staging
Nitrogen Mustard Compounds administration & dosage
Nitrogen Mustard Compounds adverse effects
Recurrence
Retrospective Studies
Treatment Outcome
Young Adult
Antineoplastic Agents, Alkylating therapeutic use
Hodgkin Disease drug therapy
Nitrogen Mustard Compounds therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 54
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 23410099
- Full Text :
- https://doi.org/10.3109/10428194.2013.776165