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Combined NK₁ antagonism and serotonin reuptake inhibition: effects on emotional processing in humans.
- Source :
-
Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2013 May; Vol. 27 (5), pp. 435-43. Date of Electronic Publication: 2013 Feb 12. - Publication Year :
- 2013
-
Abstract
- Background: Synergistic effects of NK₁ receptor antagonism combined with serotonin reuptake inhibition have been reported in preclinical models. GSK424887 is a selective competitive antagonist of the human NK₁ receptor and inhibitor of the serotonin transporter. However, its actions in human models of depression have not been assessed.<br />Methods: This study explored the effects of acute administration of GSK424887 compared to placebo in healthy male volunteers. The selective serotonin reuptake inhibitor (SSRI) citalopram was used as a positive control. A battery of emotional processing tasks was given at the peak time of drug effect.<br />Results: GSK424887 enhanced attentional vigilance in the dot-probe task to both positive and negative stimuli. By contrast, citalopram enhanced perception of angry, sad and happy facial expressions and increased positive bias in the facial expression recognition task. Neither drug significantly affected emotion potentiated startle responses or emotional memory.<br />Conclusions: These results suggest that acute administration of GSK424887 modulated some aspects of emotional processing but these effects were not similar to those seen previously with antidepressant agents. This was the first use of the battery of emotional processing tasks in a Phase 1 study. Repeated administration of the test and active control drugs may be needed to reliably characterise their effects.
- Subjects :
- Adult
Antidepressive Agents therapeutic use
Citalopram therapeutic use
Double-Blind Method
Facial Expression
Humans
Male
Memory drug effects
Perception drug effects
Recognition, Psychology drug effects
Young Adult
Acetamides therapeutic use
Emotions drug effects
Neurokinin-1 Receptor Antagonists
Piperidines therapeutic use
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1461-7285
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of psychopharmacology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23407644
- Full Text :
- https://doi.org/10.1177/0269881112472558