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[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].
- Source :
-
Ugeskrift for laeger [Ugeskr Laeger] 2013 Feb 11; Vol. 175 (7), pp. 428-32. - Publication Year :
- 2013
-
Abstract
- Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of sugammadex - an antidote to the NMB rocuronium - which within 1-3 minutes neutralizes the effects of rocuronium. High-dose rocuronium is now an alternative to suxamethonium in acute or short procedures and in a situation, where ventilation/intubating cannot be performed, sugammadex can reverse the rocuronium blockade within minutes.
- Subjects :
- Androstanols chemistry
Androstanols pharmacology
Anesthesia methods
Anesthesia Recovery Period
Humans
Intubation, Intratracheal
Neostigmine pharmacology
Neuromuscular Blockade methods
Neuromuscular Nondepolarizing Agents chemistry
Neuromuscular Nondepolarizing Agents pharmacology
Rocuronium
Sugammadex
Time Factors
gamma-Cyclodextrins adverse effects
gamma-Cyclodextrins chemistry
Androstanols antagonists & inhibitors
Neuromuscular Nondepolarizing Agents antagonists & inhibitors
gamma-Cyclodextrins pharmacology
Subjects
Details
- Language :
- Danish
- ISSN :
- 1603-6824
- Volume :
- 175
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Ugeskrift for laeger
- Publication Type :
- Academic Journal
- Accession number :
- 23402253