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Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study.
- Source :
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Molecular immunology [Mol Immunol] 2013 Jul; Vol. 54 (3-4), pp. 408-14. Date of Electronic Publication: 2013 Feb 11. - Publication Year :
- 2013
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Abstract
- Background: Lectin complement pathway (LP) activation is an important mechanism in myocardial ischemia reperfusion injury (IRI). LP is activated via the recognition molecules mannose-binding lectin (MBL), ficolins-2 and-3 and is regulated by MBL/Ficolin-associated Protein-1 (MAP-1). Also, C-reactive protein (CRP) and ficolin-2 interact in vitro, but the role of the ficolins in IRI is unknown.<br />Methods and Results: In 55 patients with ST segment elevation myocardial infarction, we investigated the association of LP components and CRP in plasma samples with left ventricular (LV) end systolic and diastolic volumes (ESV and EDV) and infarct size, assessed by cardiac magnetic resonance early at 1-3 days after primary percutaneous coronary intervention and at 6 months follow-up. Opposed to MBL, ficolin-3 and MAP-1, ficolin-2 levels were low at baseline. At baseline, ficolin-2>median was associated with ESV and EDV increases by 7.83 ml/m(2) (p=0.004) and 14.04 ml/m(2) (p<0.001). MBL and MAP-1 were not associated with LV dilatation, yet ficolin-2 and MBL worked synergistically and the combination of their levels>median was associated with ESV (11.21 ml/m(2); p=0.017) and EDV increases (14.72 ml/m(2); p=0.006). MAP-1<median+ficolin-2>median had the greatest LV dilatation (17.61 ml/m(2)). The ficolin-2 × CRP interaction variable was positively associated with infarct size and inversely associated with EDV change over 6 months (p=0.006). There was no interaction between CRP and the other LP molecules.<br />Conclusion: The LP initiator molecule ficolin-2 and combinations of ficolin-2, MBL and MAP-1 are associated with LV dilatation after myocardial infarction. Interaction of ficolin-2 and CRP was associated with infarct size and LV remodeling, indicating a potential role for LP and LP-pentraxin cross-activation in IRI and LV remodeling.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptor Proteins, Signal Transducing metabolism
Apoptosis Regulatory Proteins metabolism
Double-Blind Method
Female
Follow-Up Studies
Glycoproteins metabolism
Humans
Lectins metabolism
Magnetic Resonance Imaging methods
Male
Mannose-Binding Lectins metabolism
Middle Aged
Prospective Studies
Randomized Controlled Trials as Topic
Retrospective Studies
Ficolins
C-Reactive Protein metabolism
Complement Pathway, Mannose-Binding Lectin physiology
Myocardial Infarction metabolism
Myocardial Infarction pathology
Ventricular Remodeling physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 54
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23399387
- Full Text :
- https://doi.org/10.1016/j.molimm.2013.01.008