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Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2013 Feb 15; Vol. 92 (2), pp. 2058-64. Date of Electronic Publication: 2012 Nov 23. - Publication Year :
- 2013
-
Abstract
- Glucomannan (GM) is a polysaccharide obtained from Heterodermia obscurata lichens. The present study was conducted to elucidate the antinociceptive effect of GM in behavioural models of acute and chronic pain in mice. GM reduced mechanical allodynia and the levels of interleukin 1-β (IL-1β) in spinal cord and nerve in the partial sciatic nerve ligation (PSNL) model. Systemic treatment with GM inhibited the nociception induced by intraplantar injection of glutamate and by intrathecal injection of N-methyl-d-aspartic acid (NMDA), (±)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), tumour necrosis factor α (TNF-α) and IL-1β. Taken together, our data demonstrate that GM has significant antinociceptive effect in acute and chronic pain, suggesting a potential interest in the development of new clinically relevant drugs for the management of pain.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Acute Pain etiology
Acute Pain metabolism
Acute Pain physiopathology
Analgesics therapeutic use
Animals
Behavior, Animal drug effects
Chronic Pain etiology
Chronic Pain metabolism
Chronic Pain physiopathology
Excitatory Amino Acids administration & dosage
Excitatory Amino Acids pharmacology
Glutamic Acid pharmacology
Hyperalgesia drug therapy
Interleukin-1beta pharmacology
Ligation adverse effects
Male
Mannans therapeutic use
Mice
Motor Activity drug effects
Nociception drug effects
Sciatic Nerve drug effects
Sciatic Nerve metabolism
Sciatic Nerve surgery
Spinal Cord drug effects
Spinal Cord metabolism
Tumor Necrosis Factor-alpha pharmacology
Acute Pain drug therapy
Analgesics isolation & purification
Analgesics pharmacology
Ascomycota chemistry
Chronic Pain drug therapy
Mannans isolation & purification
Mannans pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 92
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 23399258
- Full Text :
- https://doi.org/10.1016/j.carbpol.2012.11.041