Back to Search
Start Over
Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Mar 18; Vol. 49 (22), pp. 2249-2251. - Publication Year :
- 2013
-
Abstract
- Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.
- Subjects :
- Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Colonic Neoplasms pathology
Crystallography, X-Ray
Dose-Response Relationship, Drug
Humans
Mice
Mice, Inbred BALB C
Models, Molecular
Molecular Structure
Organoplatinum Compounds chemical synthesis
Organoplatinum Compounds chemistry
Prodrugs chemical synthesis
Prodrugs chemistry
Structure-Activity Relationship
Sulfhydryl Compounds chemistry
Antineoplastic Agents pharmacology
Colonic Neoplasms drug therapy
Drug Delivery Systems
Maleimides chemistry
Organoplatinum Compounds pharmacology
Prodrugs pharmacology
Serum Albumin analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 49
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23396381
- Full Text :
- https://doi.org/10.1039/c3cc39258a