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Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy.
- Source :
-
BMC cancer [BMC Cancer] 2013 Feb 08; Vol. 13, pp. 71. Date of Electronic Publication: 2013 Feb 08. - Publication Year :
- 2013
-
Abstract
- Background: Since the definition of different histologic subtypes of urothelial carcinomas by the World Health Organization (WHO) 2004 classification, description of molecular features and clinical behavior of these variants has gained more attention.<br />Methods: We reviewed 205 tumor samples of patients with locally advanced bladder cancer mainly treated within the randomized AUO-AB05/95 trial with radical cystectomy and adjuvant cisplatin-based chemotherapy for histologic subtypes. 178 UC, 18 plasmacytoid (PUC) and 9 micropapillary (MPC) carcinomas of the bladder were identified. Kaplan Meier analysis and backward multivariate Cox's proportional hazards regression analysis were performed to compare overall survival between the three histologic subtypes.<br />Results: Patients suffering from PUC have the worst clinical outcome regarding overall survival compared to conventional UC and MPC of the bladder that in turn seem have to best clinical outcome (27.4 months, 62.6 months, and 64.2 months, respectively; p=0.013 by Kaplan Meier analysis). Backward multivariate Cox´s proportional hazards regression analysis (adjusted to relevant clinicopathological parameters) showed a hazard ratio of 3.2 (p=0.045) for PUC in contrast to patients suffering from MPC.<br />Conclusions: Histopathological diagnosis of rare variants of urothelial carcinoma can identify patients with poor prognosis.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Carcinoma classification
Carcinoma mortality
Carcinoma pathology
Carcinoma, Papillary drug therapy
Carcinoma, Papillary pathology
Carcinoma, Papillary surgery
Chemotherapy, Adjuvant
Cisplatin administration & dosage
Female
Germany
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Urinary Bladder Neoplasms classification
Urinary Bladder Neoplasms mortality
Urinary Bladder Neoplasms pathology
Urothelium pathology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma drug therapy
Carcinoma surgery
Cystectomy adverse effects
Cystectomy mortality
Urinary Bladder Neoplasms drug therapy
Urinary Bladder Neoplasms surgery
Urothelium drug effects
Urothelium surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23394492
- Full Text :
- https://doi.org/10.1186/1471-2407-13-71