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Targeting the HGF/c-MET pathway in hepatocellular carcinoma.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2013 May 01; Vol. 19 (9), pp. 2310-8. Date of Electronic Publication: 2013 Feb 06. - Publication Year :
- 2013
-
Abstract
- Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and mortality worldwide. Despite improvements in local therapies, including surgical resection, liver transplantation, and transarterial embolization, the prognosis remains poor for the majority of patients who develop recurrence or present with advanced disease. Systemic therapy with the tyrosine kinase inhibitor sorafenib represents a milestone in advanced HCC but provides a limited survival benefit. Ongoing efforts to study hepatocarcinogenesis have identified an important role for c-MET signaling in the promotion of tumor growth, angiogenesis, and metastasis. In this review, we summarize the preclinical data from human tissue, cell lines, and animal models that implicate c-MET in the pathogenesis of HCC. We also evaluate potential biomarkers that may estimate prognosis or predict response to c-MET inhibitors for more rational clinical trial design. Finally, we discuss the latest clinical trials of c-MET inhibitors in advanced HCC.<br /> (©2013 AACR.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Carcinoma, Hepatocellular metabolism
Clinical Trials as Topic
Humans
Liver Neoplasms metabolism
Molecular Targeted Therapy
Proto-Oncogene Proteins c-met metabolism
Signal Transduction
Antineoplastic Agents pharmacology
Carcinoma, Hepatocellular drug therapy
Hepatocyte Growth Factor physiology
Liver Neoplasms drug therapy
Proto-Oncogene Proteins c-met antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3265
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 23388504
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-12-2791