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Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS).
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2013 Mar; Vol. 98 (3), pp. 995-1005. Date of Electronic Publication: 2013 Feb 05. - Publication Year :
- 2013
-
Abstract
- Context: There is little information on the potential impact of serum 1,25-dihydroxyvitamin D [1,25(OH)2D] on bone health including turnover.<br />Objective: The objective of the study was to determine the influence of 1,25(OH)2D and 25-hydroxyvitamin D [25(OH)D] on bone health in middle-aged and older European men.<br />Design, Setting, and Participants: Men aged 40-79 years were recruited from population registers in 8 European centers. Subjects completed questionnaires that included questions concerning lifestyle and were invited to attend for quantitative ultrasound (QUS) of the heel, assessment of height and weight, and a fasting blood sample from which 1,25(OH)2D, 25(OH)D, and PTH were measured. 1,25(OH)2D was measured using liquid chromatography tandem mass spectrometry. Bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β-cTX) were also measured. Dual-energy x-ray absorptiometry (DXA) of the hip and lumbar spine was performed in 2 centers.<br />Main Outcome Measure(s): QUS of the heel, bone markers P1NP and β-cTX, and DXA of the hip and lumbar spine were measured.<br />Results: A total of 2783 men, mean age 60.0 years (SD 11.0) were included in the analysis. After adjustment for age and center, 1,25(OH)2D was positively associated with 25(OH)D but not with PTH. 25(OH)D was negatively associated with PTH. After adjustment for age, center, height, weight, lifestyle factors, and season, 1,25(OH)2D was associated negatively with QUS and DXA parameters and associated positively with β-cTX. 1,25(OH)2D was not correlated with P1NP. 25(OH)D was positively associated with the QUS and DXA parameters but not related to either bone turnover marker. Subjects with both high 1,25(OH)2D (upper tertile) and low 25(OH)D (lower tertile) had the lowest QUS and DXA parameters and the highest β-cTX levels.<br />Conclusions: Serum 1,25(OH)2D is associated with higher bone turnover and poorer bone health despite being positively related to 25(OH)D. A combination of high 1,25(OH)2D and low 25(OH)D is associated with the poorest bone health.
- Subjects :
- Absorptiometry, Photon
Adult
Aged
Biomarkers metabolism
Bone Density physiology
Bone Diseases, Metabolic diagnostic imaging
Calcaneus diagnostic imaging
Calcaneus metabolism
Collagen Type I metabolism
Hip Joint diagnostic imaging
Humans
Life Style
Lumbar Vertebrae diagnostic imaging
Lumbar Vertebrae metabolism
Male
Middle Aged
Parathyroid Hormone blood
Peptides metabolism
Surveys and Questionnaires
Ultrasonography
Vitamin D blood
White People
Aging metabolism
Bone Diseases, Metabolic metabolism
Bone Remodeling physiology
Calcitriol blood
Vitamin D analogs & derivatives
Vitamin D Deficiency metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 98
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23386642
- Full Text :
- https://doi.org/10.1210/jc.2012-2772