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Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville.
- Source :
-
Malaria journal [Malar J] 2013 Feb 05; Vol. 12, pp. 53. Date of Electronic Publication: 2013 Feb 05. - Publication Year :
- 2013
-
Abstract
- Background: Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated Plasmodium falciparum malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo.<br />Methods: One hundred and ninety-seven patients (96 ≤ 5 years old and 101 >5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. Plasmodium falciparum recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence.<br />Results: The overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged ≤ 5 years old and those aged >5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain.<br />Conclusion: This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Congo
Drug Combinations
Female
Humans
Infant
Male
Middle Aged
Plasmodium falciparum classification
Plasmodium falciparum genetics
Plasmodium falciparum isolation & purification
Polymerase Chain Reaction
Treatment Outcome
Young Adult
Amodiaquine administration & dosage
Artemisinins administration & dosage
Malaria, Falciparum drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2875
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Malaria journal
- Publication Type :
- Academic Journal
- Accession number :
- 23384005
- Full Text :
- https://doi.org/10.1186/1475-2875-12-53