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Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type.
- Source :
-
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2013 Mar 19; Vol. 185 (5), pp. E229-37. Date of Electronic Publication: 2013 Feb 04. - Publication Year :
- 2013
-
Abstract
- Background: ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor V Leiden R506Q and prothrombin G20210A is associated with the risk of venous thromboembolism and myocardial infarction in the general population.<br />Methods: We used data from 2 Danish studies that followed members of the general public from 1977 through 2010. We obtained the genotype of 66 001 white participants for ABO blood type, factor V Leiden R506Q and prothrombin G20210A. We calculated hazard ratios (HRs) and population attributable risk. Our main outcome measures were venous thromboembolism and myocardial infarction.<br />Results: The multivariable adjusted HR for venous thromboembolism was 1.4 (95% confidence interval [CI] 1.3-1.5) for non-O blood type (v. O blood type). For the factor V Leiden R506Q mutation, the adjusted HR was 2.2 (95% CI 2.0-2.5) for heterozygous participants and 7.0 (95%CI 4.8-10) for homozygous participants (v. participants without the mutation). For prothrombin G20210A, the adjusted HR was 1.5 (95%CI 1.2-1.9) for heterozygous participants and 11 (95% CI 2.8-44) for homozygous participants (v. participants without the mutation). When we combined ABO blood type and factor V Leiden R506Q or prothrombin G20210A genotype, there was a stepwise increase in the risk of venous thromboembolism (trend, p<0.001). The population attributable risk of venous thromboembolism was 20% for ABO blood type, 10% for factor V Leiden R506Q and 1% for prothrombin G20210A. Multivariable adjusted HRs for myocardial infarction by genotypes did not differ from 1.0.<br />Interpretation: ABO blood type had an additive effect on the risk of venous thromboembolism when combined with factor V Leiden R506Q and prothrombin G20210A mutations; blood type was the most important risk factor for venous thromboembolism in the general population.
- Subjects :
- Age Factors
Aged
Cohort Studies
Denmark epidemiology
Female
Genetic Testing
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Mutation
Myocardial Infarction epidemiology
Myocardial Infarction physiopathology
Polymorphism, Genetic
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Sex Factors
Statistics, Nonparametric
Survival Rate
Venous Thromboembolism epidemiology
Venous Thromboembolism physiopathology
ABO Blood-Group System genetics
Factor V genetics
Genetic Predisposition to Disease epidemiology
Myocardial Infarction genetics
Prothrombin genetics
Venous Thromboembolism genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1488-2329
- Volume :
- 185
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
- Publication Type :
- Academic Journal
- Accession number :
- 23382263
- Full Text :
- https://doi.org/10.1503/cmaj.121636