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The development of a new desensitising mouthwash containing arginine, PVM/MA copolymer, pyrophosphates, and sodium fluoride--a hydraulic conductance study.
- Source :
-
Journal of dentistry [J Dent] 2013 Mar; Vol. 41 Suppl 1, pp. S20-5. Date of Electronic Publication: 2013 Feb 01. - Publication Year :
- 2013
-
Abstract
- Objective: To investigate the ability of a novel mouthwash comprised of 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (Pro-Argin™ Mouthwash Technology) to reduce dentine permeability.<br />Methods: Hydraulic conductance was used to assess the dentine permeability effects of the arginine mouthwash. Aqueous solutions containing arginine and PVM/MA copolymer were studied in the initial stage of the method development. The acid resistance was tested with a cola drink challenge. Finally, a blinded study was carried out to determine the occlusion of the arginine mouthwash in comparison to a negative control mouthwash.<br />Results: Dentine discs treated with the arginine mouthwash showed an average fluid reduction of 42%, which was statistically, significantly better than the fluid reduction for the negative control mouthwash. In addition, experiments using simple solutions of arginine and PVM/MA copolymer, alone and in combination, demonstrated that the combination of the two was required to provide a relevant occlusion benefit. Finally, the occlusion provided by the arginine mouthwash was maintained after exposure to an acid challenge.<br />Conclusion: The exclusive combination of ingredients in the arginine mouthwash has been proven to be efficacious in decreasing dentine fluid flow as measured by hydraulic conductance. The new mouthwash works by occlusion, due to the unique combination of arginine, PVM/MA copolymer and pyrophosphates.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Diphosphates chemical synthesis
Drug Combinations
Drug Compounding
Humans
Hydrodynamics
Sodium Fluoride chemical synthesis
Arginine chemical synthesis
Calcium Carbonate chemical synthesis
Dentin Desensitizing Agents chemical synthesis
Fluorides chemical synthesis
Maleates chemical synthesis
Mouthwashes chemical synthesis
Phosphates chemical synthesis
Polyethylenes chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1879-176X
- Volume :
- 41 Suppl 1
- Database :
- MEDLINE
- Journal :
- Journal of dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 23380073
- Full Text :
- https://doi.org/10.1016/j.jdent.2012.11.017