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M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.
- Source :
-
Retrovirology [Retrovirology] 2013 Feb 01; Vol. 10, pp. 12. Date of Electronic Publication: 2013 Feb 01. - Publication Year :
- 2013
-
Abstract
- Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.<br />Findings: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.<br />Conclusions: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
- Subjects :
- Disease Transmission, Infectious prevention & control
Female
HIV Infections prevention & control
HIV Infections transmission
Humans
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear virology
Mucous Membrane virology
Vagina virology
Anti-HIV Agents metabolism
Biomimetics
CD4 Antigens metabolism
HIV Envelope Protein gp120 antagonists & inhibitors
HIV-1 drug effects
Virion drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4690
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 23375046
- Full Text :
- https://doi.org/10.1186/1742-4690-10-12