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Effect of IR laser on myoblasts: a proteomic study.
- Source :
-
Molecular bioSystems [Mol Biosyst] 2013 Jun; Vol. 9 (6), pp. 1147-61. - Publication Year :
- 2013
-
Abstract
- Laser therapy is used in physical medicine and rehabilitation to accelerate muscle recovery and in sports medicine to prevent damages produced by metabolic disturbances and inflammatory reactions after heavy exercise. The aim of this research was to get insight into possible benefits deriving from the application of an advanced IR laser system to counteract deficits of muscle energy metabolism and stimulate the recovery of hypotrophic tissue. We studied the effect of IR laser treatment on proliferation, differentiation, cytoskeleton organization and global protein expression in C2C12 myoblasts. We found that laser treatment induced a decrease in the cell proliferation rate without affecting cell viability, while leading to cytoskeletal rearrangement and expression of the early differentiation marker MyoD. The differential proteome analysis revealed the up-regulation and/or modulation of many proteins known to be involved in cell cycle regulation, cytoskeleton organization and differentiation.
- Subjects :
- Animals
Cell Cycle
Cell Differentiation radiation effects
Cell Line
Cell Proliferation radiation effects
Cytoskeleton
Gene Expression radiation effects
Lasers
Mice
Muscle, Skeletal cytology
MyoD Protein radiation effects
Myoblasts cytology
Myoblasts metabolism
Proteomics
Up-Regulation
Energy Metabolism radiation effects
Infrared Rays
Laser Therapy
Muscle, Skeletal metabolism
Muscle, Skeletal radiation effects
MyoD Protein metabolism
Myoblasts radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1742-2051
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecular bioSystems
- Publication Type :
- Academic Journal
- Accession number :
- 23364335
- Full Text :
- https://doi.org/10.1039/c2mb25398d