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Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats.
- Source :
-
International journal of food sciences and nutrition [Int J Food Sci Nutr] 2013 Aug; Vol. 64 (5), pp. 575-86. Date of Electronic Publication: 2013 Jan 30. - Publication Year :
- 2013
-
Abstract
- Saturated and trans fatty acids have been associated with the risk to develop cardiovascular diseases. However, health-promoting effects are associated with consumption of anhydrous milk fat (AMF) and ruminant trans fatty acids, such as conjugated linoleic acid (CLA) and vaccenic acid (VA) contained in the lipid fraction of milk and dairy products. The purpose of this study was to evaluate the effect of AMF naturally enriched with CLA and VA in spontaneously hypertensive rats (SHR), using sterculic oil to inhibit the conversion of VA into CLA. The administration of AMF to SHR during 7 weeks exerted beneficial effects on cardiovascular risk biomarkers (reduction of insulin, blood lipids, increase of adiponectin). When sterculic oil was included, some parameters were further ameliorated (reduction of insulin, increase of adiponectin). Sterculic oil alone reduced body weight and adiposity, and improved blood pressure, adiponectin and triglyceride levels.
- Subjects :
- Adiponectin blood
Adiposity drug effects
Animals
Biomarkers blood
Blood Pressure drug effects
Cardiovascular Diseases etiology
Cardiovascular Diseases prevention & control
Cyclopropanes pharmacology
Cyclopropanes therapeutic use
Diet
Dietary Fats pharmacology
Fatty Acids, Monounsaturated pharmacology
Fatty Acids, Monounsaturated therapeutic use
Hypertension blood
Insulin blood
Linoleic Acid pharmacology
Linoleic Acids, Conjugated pharmacology
Lipids blood
Male
Oleic Acids pharmacology
Rats
Rats, Inbred SHR
Ruminants
Triglycerides blood
Weight Loss drug effects
Cardiovascular Diseases blood
Dietary Fats therapeutic use
Hypertension drug therapy
Linoleic Acid therapeutic use
Linoleic Acids, Conjugated therapeutic use
Milk chemistry
Oleic Acids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3478
- Volume :
- 64
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of food sciences and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 23360131
- Full Text :
- https://doi.org/10.3109/09637486.2013.763908