Back to Search
Start Over
Crocetin administration ameliorates endotoxin-induced disseminated intravascular coagulation in rabbits.
- Source :
-
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis [Blood Coagul Fibrinolysis] 2013 Apr; Vol. 24 (3), pp. 305-10. - Publication Year :
- 2013
-
Abstract
- Disseminated intravascular coagulation (DIC), a life-threatening secondary complication in several diseases, is characterized by large amounts of thrombin that lead to fibrin deposition and microthrombus formation throughout the microcirculation. Recent in-vitro studies suggest that crocin, crocetin or safranal, carotenoid constituents of the spice Crocus sativus L. (saffron), have antithrombotic properties, especially anti-Xa activity. The present study was designed to evaluate the effect of crocetin on thrombosis procedure using a rabbit model of bacterial endotoxin-induced DIC. Crocetin administration (3 mg/kg), 30 min before the beginning of endotoxin infusion, improved DIC-related haemostatic indices such as platelet blood counts (P≤ 0.05), blood plasma fibrinogen and protein C concentration (P≤ 0.05). In addition, it ameliorated DIC-associated disease and fibrin deposition in the glomeruli (P≤ 0.05). These results indicate that crocetin reveals a preventive antithrombotic role in vivo and prescribe further investigation on the possibility of developing crocetin-based DIC treatment modalities.
- Subjects :
- Animals
Disseminated Intravascular Coagulation blood
Disseminated Intravascular Coagulation chemically induced
Endotoxins
Fibrinogen metabolism
Male
Platelet Count
Protein C metabolism
Rabbits
Thrombin metabolism
Vitamin A analogs & derivatives
Antioxidants pharmacology
Blood Platelets drug effects
Carotenoids pharmacology
Disseminated Intravascular Coagulation drug therapy
Fibrinolytic Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5733
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
- Publication Type :
- Academic Journal
- Accession number :
- 23358225
- Full Text :
- https://doi.org/10.1097/MBC.0b013e32835bdc8f