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Prognostic significance of the expression of GFRα1, GFRα3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma.
- Source :
-
BMC cancer [BMC Cancer] 2013 Jan 26; Vol. 13, pp. 34. Date of Electronic Publication: 2013 Jan 26. - Publication Year :
- 2013
-
Abstract
- Background: Artemin (ARTN) has been implicated in promoting oncogenicity, tumor growth and invasiveness in diverse human malignancies. However, the clinical and prognostic significance of upstream ligand binding components, potentially mediating ARTN oncogenicity, largely remain to be determined.<br />Methods: We determined the mRNA and protein expression of three proteins demonstrated to bind ARTN, namely GFRα1, GFRα3 and syndecan-3 (SDC3), in benign breast disease and mammary carcinoma by in situ hybridization and immunohistochemistry, respectively. Their prognostic significance combined with ARTN expression was also investigated in mammary carcinoma.<br />Results: The expression of GFRα1 and GFRα3, but not SDC3, was significantly increased in mammary carcinoma and positively associated with tumor lymph node metastases, higher clinical stage and HER-2 positivity. Moreover, both GFRα1 and GFRα3 expression were significantly associated with survival outcome of patients with mammary carcinoma by univariate and multivariate analyses, whereas expression of SDC3 was not. Co-expression of ARTN with either GFRα1 or GFRα3, but not SDC3, produced synergistic increases in the odds ratio for both relapse-free and overall survival in patients with mammary carcinoma. Furthermore, significant association of GFRα1 and GFRα3 expression with survival outcome observed herein were restricted to ER negative or HER-2 negative mammary carcinoma.<br />Conclusions: The expression of GFRα1 and/or GFRα3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma.
- Subjects :
- Adenocarcinoma, Mucinous chemistry
Biomarkers, Tumor genetics
Breast Neoplasms genetics
Breast Neoplasms mortality
Breast Neoplasms pathology
Carcinoma metabolism
Carcinoma mortality
Carcinoma secondary
Carcinoma, Ductal, Breast chemistry
Carcinoma, Lobular chemistry
Chi-Square Distribution
Disease-Free Survival
Female
Glial Cell Line-Derived Neurotrophic Factor Receptors genetics
Humans
Immunohistochemistry
In Situ Hybridization
Kaplan-Meier Estimate
Lymphatic Metastasis
Multivariate Analysis
Neoplasm Staging
Odds Ratio
Proportional Hazards Models
RNA, Messenger analysis
Receptor, ErbB-2 analysis
Risk Factors
Syndecan-3 genetics
Time Factors
Biomarkers, Tumor analysis
Breast Neoplasms chemistry
Carcinoma chemistry
Glial Cell Line-Derived Neurotrophic Factor Receptors analysis
Nerve Tissue Proteins analysis
Syndecan-3 analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23351331
- Full Text :
- https://doi.org/10.1186/1471-2407-13-34