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Time courses of behavioral and regional cerebral metabolic responses to different doses of meta-chlorophenylpiperazine in awake rats.
- Source :
-
Brain research [Brain Res] 1990 Mar 19; Vol. 511 (2), pp. 209-16. - Publication Year :
- 1990
-
Abstract
- The time course and relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) and of motor behavior were measured in awake male adult Fischer-344 rats after administration of meta-chlorophenylpiperazine (MCPP), a serotonin-1B receptor agonist. rCMRglc was determined, using the quantitative autoradiographic [14C]deoxyglucose technique, in 71 brain regions at 5, 15, 30 and 60 min after administration of MCPP 2.5 mg/kg i.p., and at 15 min after MCPP 25 and 40 mg/kg. The time course of performance on a rotating rod was measured periodically for 60 min after MCPP 2.5 mg/kg, a dose which impaired locomotion and reduced rCMRglc maximally at 15-30 min after its administration. At 15 min, rCMRglc declined significantly in 28 (40%) of the areas studied (mean decline 16%). Most regions affected were telencephalic or diencephalic, corresponding to the projection areas of serotonergic fibers arising from the raphe nuclei. After higher doses of MCPP, a behavioral serotonin syndrome was observed with both rCMRglc increases and decreases (25 mg/kg) or only rCMRglc increases (40 mg/kg). Whereas behavioral and metabolic activation induced by high doses of MCPP may result from stimulation at postsynaptic serotonin receptors, rCMRglc reductions and hypomotility produced by MCPP 2.5 mg/kg resemble the effects of serotonin receptor antagonists and suggest that, at this low dose, MCPP acts at modulatory serotonin autoreceptors to reduce endogenous serotonin release.
- Subjects :
- Animals
Brain drug effects
Dose-Response Relationship, Drug
Male
Rats
Rats, Inbred F344
Receptors, Serotonin drug effects
Behavior, Animal drug effects
Brain metabolism
Deoxy Sugars pharmacokinetics
Deoxyglucose pharmacokinetics
Glycolates pharmacology
Motor Activity drug effects
Piperazines pharmacology
Receptors, Serotonin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 511
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 2334843
- Full Text :
- https://doi.org/10.1016/0006-8993(90)90163-6