Back to Search
Start Over
Supramolecular hydrogels from in situ host-guest inclusion between chemically modified cellulose nanocrystals and cyclodextrin.
- Source :
-
Biomacromolecules [Biomacromolecules] 2013 Mar 11; Vol. 14 (3), pp. 871-80. Date of Electronic Publication: 2013 Feb 04. - Publication Year :
- 2013
-
Abstract
- When grafted β-cyclodextrin is used as targeting sites, Pluronic polymers have been introduced on the surface of cellulose nanocrystals by means of inclusion interaction between β-cyclodextrin and hydrophobic segment of the polymer. Because of the steric stabilization effect, surface poly(ethylene glycol) chains facilitate the dispersion and compatibility of nanocrystals, which also enhance the loading levels of nanocrystals in the hydrogel system. Meanwhile, uncovered poly(ethylene glycol) segments render the participating inclusion of α-cyclodextrin for the architecture of in situ hydrogels. Surface grafting and inclusion reactions were proved by solid (13)C NMR and FTIR. Grafting efficiency of β-cyclodextrin and inclusion efficiency of Pluronic on the surface of nanocrystals were confirmed by UV spectroscopy and elemental analysis. A significant enhancement of the structural and thermal stability of in situ hydrogels with high loading levels of modified nanocrystals (>5.77 wt %) was observed by rheological analysis. Further study reveals the performance and behavior of hydrogels under a different pH environment. Finally, in situ hydrogels were used as drug carrier for in vitro release of doxorubicin and exhibit the behavior of prolonged drug release with special release kinetics.
- Subjects :
- Doxorubicin chemistry
Doxorubicin pharmacology
Drug Carriers
Hydrophobic and Hydrophilic Interactions
Magnetic Resonance Spectroscopy
Microscopy, Electron, Transmission
Poloxamer chemistry
Polyethylene Glycols chemistry
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Cellulose chemistry
Cyclodextrins chemistry
Hydrogels chemistry
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4602
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 23347071
- Full Text :
- https://doi.org/10.1021/bm301955k