Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening.

Authors :: Aytan H
Caliskan AC
Demirturk F
Sahin S
Erdogan F
Kuzu Z
Source :: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2013 Jun; Vol. 287 (6), pp. 1125-9. Date of Electronic Publication: 2013 Jan 23.
Publication Year :: 2013
Abstract: Purpose: The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels as the biochemical markers of the combined first trimester aneuploidy screening.<br />Methods: 375 pregnant women between 11 and 14 weeks of gestation who were offered routine first trimester prenatal aneuploidy screening and whose thyroid hormone levels (Thyroid stimulating hormone (TSH), free and total thyroxine, free and total triiodothyronine, anti thyroid peroxidase antibody) were measured were assessed. Correlation of free-β-hCG and PAPP-A with maternal thyroid hormones was analyzed.<br />Results: There was no statistically significant correlation between maternal TSH, free and total thyroxine, free and total triiodothyronine, anti-thyroid peroxidase antibodies and free-β-hCG and PAPP-A as biochemical markers of first trimester aneuploidy screening.<br />Conclusion: Maternal thyroid function does not seem to affect secretion of fβ-hCG and PAPP-A.

Subjects :: Adult
Biomarkers blood
Down Syndrome diagnosis
Female
Humans
Hyperthyroidism diagnosis
Hypothyroidism diagnosis
Maternal Age
Pregnancy
Pregnancy Complications diagnosis
Retrospective Studies
Thyrotropin blood
Thyroxine blood
Aneuploidy
Chorionic Gonadotropin, beta Subunit, Human blood
Gestational Age
Pregnancy-Associated Plasma Protein-A analysis
Prenatal Diagnosis
Thyroid Hormones blood

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