Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy.

Authors :: Wang H
Wu Y
Zhao R
Nie G
Source :: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2013 Mar 20; Vol. 25 (11), pp. 1616-22. Date of Electronic Publication: 2013 Jan 22.
Publication Year :: 2013
Abstract: The rapid development of nanotechnology holds great promise for revolutionizing the current landscape of tumor drug delivery. However, one of the biggest challenges is developing a simple nanocarrier platform to co-deliver various therapeutic agents. Here, a strategy for fabricating nanocarriers with many desirable features is demonstrated. The resulting nanoparticles achieve both high antitumor efficacy and effective inhibition of tumor metastasis with minimal side effects.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Cell Survival drug effects
Doxorubicin administration & dosage
Fluorescein-5-isothiocyanate chemistry
Lung Neoplasms drug therapy
Lung Neoplasms secondary
Melanoma, Experimental pathology
Mice
Nanomedicine
Nanoparticles therapeutic use
Nanoparticles toxicity
Paclitaxel administration & dosage
Polyethylene Glycols chemistry
Polyglutamic Acid analogs & derivatives
Polyglutamic Acid chemistry
Antineoplastic Agents administration & dosage
Drug Carriers chemistry
Nanoparticles chemistry

Full Text Access

Tools