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Nephroprotective effect of jaggery against acute and subchronic toxicity of acetaminophen in Wistar rats.
- Source :
-
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 2012; Vol. 31 (3), pp. 265-72. - Publication Year :
- 2012
-
Abstract
- The present investigation was planned to evaluate the nephroprotective activity of jaggery against acetaminophen (APAP)-induced renal damage in rats. The protective activity of jaggery at different doses (250, 500, and 750 mg/kg, orally) was evaluated against oxidative damage induced by APAP administration (2 g/kg, once orally in acute exposure; 20 mg/kg, orally for 21 days in subchronic exposure) in rats. APAP administration significantly increased the levels of serum urea, creatinine, and renal lipid peroxidation (LPO), whereas substantial decreases were observed in levels of glutathione (GSH), adenosine triphosphatase (ATPase), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) enzymatic activities after APAP administration. Administration of jaggery significantly moved the studied parameters toward normal levels and also reversed the histopathologic alterations. Thus, jaggery can be used to reduce renal damage and may serve as an alternative medicine in the treatment of renal etiologies.
- Subjects :
- Acetaminophen toxicity
Analgesics, Non-Narcotic toxicity
Animals
Blood Chemical Analysis
Catalase metabolism
Dose-Response Relationship, Drug
Glutathione metabolism
Glutathione Peroxidase metabolism
Kidney enzymology
Kidney pathology
Kidney Function Tests
Lipid Peroxidation
Male
Oxidative Stress drug effects
Plant Extracts administration & dosage
Rats
Rats, Wistar
Superoxide Dismutase metabolism
Acetaminophen antagonists & inhibitors
Analgesics, Non-Narcotic antagonists & inhibitors
Kidney drug effects
Phytotherapy
Plant Extracts therapeutic use
Saccharum
Subjects
Details
- Language :
- English
- ISSN :
- 2162-6537
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23339700
- Full Text :
- https://doi.org/10.1615/jenvironpatholtoxicoloncol.v31.i3.70