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Eleutherine indica L. accelerates in vivo cutaneous wound healing by stimulating Smad-mediated collagen production.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2013 Mar 27; Vol. 146 (2), pp. 490-4. Date of Electronic Publication: 2013 Jan 18. - Publication Year :
- 2013
-
Abstract
- Ethnopharmacological Relevance: Eleutherine indica L. has been used for healing of wound, painful and irregular menstruation, dysentery and lesions, and topically used as antiseptic and antimicrobial agent in folk medicine. In the present study, methanolic extracts of Eleutherine indica was subjected to scientific investigation for in-vivo cutaneous wound healing in wistar rat.<br />Materials and Methods: In-vivo wound healing activity of Eleutherine indica was evaluated by using circular excision experimental models, followed by histopathological and western blot analysis. The healing potential was comparatively assessed with a reference gentamicin sulfate hydrogel (0.01% w/w). Wound contraction measurement, hydroxyproline estimation and western blot for COL3A1, bFGF, Smad-2, -3, -4, and -7 were performed.<br />Results: The methanolic extract of Eleutherine indica showed accelerated wound healing activity as evidenced by fast wound contraction rate and higher hydroxyproline content of granulation tissue. Western blot revealed the Smad-mediated collagen production promoting property of Eleutherine indica methanolic extract. Histopathological examinations also supported the experimental findings.<br />Conclusion: The study revealed that Eleutherine indica promotes wound healing by augmenting Smad-mediated collagen production in wound granulation tissue.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Collagen metabolism
Collagen Type III metabolism
Hydroxyproline metabolism
Male
Mice
Plant Extracts pharmacology
Rats
Rats, Wistar
Skin drug effects
Skin injuries
Skin metabolism
Skin pathology
Iridaceae
Phytotherapy
Plant Extracts therapeutic use
Smad Proteins metabolism
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 146
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23337744
- Full Text :
- https://doi.org/10.1016/j.jep.2013.01.012