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Evaluation of GLUT-1 in the granular cell tumour and congenital granular cell epulis.
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2013 Jul; Vol. 42 (6), pp. 450-3. Date of Electronic Publication: 2013 Jan 22. - Publication Year :
- 2013
-
Abstract
- Background: The glucose transporter type 1 (GLUT-1) protein is a useful marker for perineurial cells. Because of the possible neuroectodermal histogenesis of the granular cell tumour and congenital granular cell epulis, the aim of this study was to assess the immunoexpression of GLUT-1 protein in granular cell tumour and congenital granular cell epulis to aid in clarifying their histogenesis.<br />Methods: The protocol of this study was approved by the Committee of Bioethics in Research at Universidade Federal Minas Gerais. Six cases of granular cell tumour and three cases of congenital granular cell epulis were submitted to immunohistochemistry for GLUT-1 and S-100 using the streptavidin-biotin standard protocol.<br />Results: Five cases of granular cell tumour were located on the tongue and one case on the upper lip. All cases of congenital granular cell epulis were observed in the alveolar ridge of newborns. All lesions evaluated proved to be immunonegative for GLUT-1. S-100 was found to be positive in all granular cell tumours and negative in congenital granular cell epulis.<br />Conclusions: Neither granular cell tumour nor congenital granular cell epulis is directly related to perineurial cells.<br /> (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Female
Gingival Neoplasms pathology
Humans
Immunohistochemistry
Infant, Newborn
Lip Neoplasms pathology
Male
Middle Aged
Neural Plate pathology
Peripheral Nerves pathology
S100 Proteins analysis
Tongue Neoplasms pathology
Gingival Neoplasms congenital
Glucose Transporter Type 1 analysis
Granular Cell Tumor pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0714
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 23336292
- Full Text :
- https://doi.org/10.1111/jop.12035