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Hepatic arterial infusion of oxaliplatin, 5-fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma.
- Source :
-
Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2012 Oct-Dec; Vol. 17 (4), pp. 677-83. - Publication Year :
- 2012
-
Abstract
- Purpose: Limited data are available regarding the efficacy of hepatic arterial infusion (HAI) of oxaliplatin in patients with liver metastases from colorectal carcinoma (CRC). The aim of the present study was to evaluate the results of HAI of oxaliplatin combined with 5-fluorouracil (5-FU) and leucovorin (LV) in patients with such metastases.<br />Methods: A retrospective analysis of 22 CRC patients treated with HAI of combination of oxaliplatin and 5-FU and LV was performed.<br />Results: Partial response (PR) was observed in 4 (18%) patients and stable disease (SD) in 7, with an overall disease control rate of 50%. The median progression-free (PFS) and overall survival (OS) were 7 and 11 months, respectively. Two patients treated with first-line treatment underwent subsequent liver resection. In 2 patients, HAI of oxaliplatin, 5-FU and LV was combined with systemic administration of bevacizumab.<br />Conclusion: Our data demonstrate reasonable efficacy of HAI with oxaliplatin, 5-FU and LV in patients with liver metastases from CRC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoembryonic Antigen blood
Female
Fluorouracil administration & dosage
Hepatic Artery
Humans
Leucovorin administration & dosage
Male
Middle Aged
Organoplatinum Compounds administration & dosage
Oxaliplatin
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Colorectal Neoplasms pathology
Infusions, Intra-Arterial
Liver Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1107-0625
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of B.U.ON. : official journal of the Balkan Union of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 23335524