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Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB.
Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB.
- Source :
-
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2013 Mar; Vol. 93 (2), pp. 155-66. Date of Electronic Publication: 2013 Jan 16. - Publication Year :
- 2013
-
Abstract
- Tuberculosis (TB) is one of the most important infectious diseases around the world. Several studies have focused on the identification of correlates of protection against TB. Most of them have concentrated on the study of IFN-γ due to its robust association with protection against TB. However, given the complexity of the immune response elicited after Mtb infection, other cytokines should also be considered. In the present study, we evaluated Th1 and Th17 responses and their association with the protection or development of active disease. Therefore, non infected individuals (nonTBi), latently infected individuals (LTBi) and patients with active TB (ATB) were studied. The evaluation of the number of cytokine producing cells by ELISPOT showed a higher number of IFN-γ-producing cells in ATB patients, but no differences were found regarding the number of IL-17 producing cells among studied groups. The evaluation of IFN-γ, IL-2, TNF-α and IL-17 producing CD4+ and CD8+ T cells at 1 day and 6 days of stimulation with mycobacterial antigens suggests the presence of functional signatures associated with latency or active TB. The results presented herein suggest the possible use of the evaluation of Th1-type cytokines, such as IFN-γ and/or TNF-α, as a correlate of protection against TB; however, these results need to be validated for other groups.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antigens, Bacterial immunology
Bacterial Proteins immunology
Humans
Immunity, Cellular
Interferon-gamma biosynthesis
Latent Tuberculosis immunology
Mycobacterium tuberculosis immunology
Th1 Cells immunology
Th17 Cells immunology
Time Factors
Tuberculin immunology
Tumor Necrosis Factor-alpha biosynthesis
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Cytokines biosynthesis
Tuberculosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-281X
- Volume :
- 93
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 23332142
- Full Text :
- https://doi.org/10.1016/j.tube.2012.12.002