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IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells.
- Source :
-
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2013 Feb; Vol. 18 (2), pp. 79-89. Date of Electronic Publication: 2013 Jan 21. - Publication Year :
- 2013
-
Abstract
- Neural precursor cells (NPCs) in the mammalian neocortex generate various neuronal and glial cell types in a developmental stage-dependent manner. Most neocortical NPCs lose their neurogenic potential after birth. We have previously shown that high-mobility group A (HMGA) proteins confer the neurogenic potential on early-stage NPCs during the midgestation period, although the underlying mechanisms are not fully understood. In this study, we found that HMGA2 promotes the expression of insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, Igf2bp2) in neocortical NPCs. The level of IMP2 was indeed high in early-stage NPCs compared with that in late-stage NPCs. Importantly, over-expression of IMP2 increased the neurogenic potential and suppressed astrocytic differentiation of late-stage NPCs, whereas knockdown of IMP2 promoted astrocytic differentiation and reduced the neurogenic potential of early-stage neocortical NPCs without overtly affecting cell proliferation. Our results thus identified IMP2 as a developmental stage-dependent regulator of the differentiation potentials of NPCs in the mouse neocortex.<br /> (© 2013 The Authors Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.)
- Subjects :
- Animals
Cell Differentiation genetics
Cell Proliferation
Cells, Cultured
Gene Expression
Gene Expression Regulation, Developmental
HMGA2 Protein metabolism
Mice
Neocortex embryology
RNA-Binding Proteins genetics
T-Box Domain Proteins genetics
T-Box Domain Proteins metabolism
Cell Differentiation physiology
Neocortex cytology
Neocortex metabolism
Neural Stem Cells cytology
Neural Stem Cells metabolism
RNA-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2443
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Genes to cells : devoted to molecular & cellular mechanisms
- Publication Type :
- Academic Journal
- Accession number :
- 23331702
- Full Text :
- https://doi.org/10.1111/gtc.12024