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Direct catalytic asymmetric alkynylation of ketoimines.
- Source :
-
Organic letters [Org Lett] 2013 Feb 01; Vol. 15 (3), pp. 698-701. Date of Electronic Publication: 2013 Jan 18. - Publication Year :
- 2013
-
Abstract
- An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 23330983
- Full Text :
- https://doi.org/10.1021/ol3035609