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Influence of metaphos on the structuro-functional organization of mitochondrial membranes.
- Source :
-
Biology bulletin of the Academy of Sciences of the USSR [Biol Bull Acad Sci USSR] 1979 Nov-Dec; Vol. 6 (6), pp. 788-93. - Publication Year :
- 1979
-
Abstract
- It has been established by methods of spectrophotometry and spin probe that the organophosphorus pesticide metaphos, widely used in practice, is an inhibitor of NADH2 oxidase of the respiratory chain of the mitochondria and exerts an influence on the structural organization of the mitochondrial membrane. An effect of metaphos on the nature of the distribution and kinetics of NADH2-induced death of monoradical spin probes of various chemical structures was detected in a suspension of submitochondrial particles obtained from beef heart.
- Subjects :
- Animals
Cattle
Electron Spin Resonance Spectroscopy
Mitochondria, Heart drug effects
Spin Labels
Submitochondrial Particles drug effects
Methyl Parathion pharmacology
Mitochondria ultrastructure
Mitochondria, Heart ultrastructure
Parathion analogs & derivatives
Submitochondrial Particles ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0098-2164
- Volume :
- 6
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biology bulletin of the Academy of Sciences of the USSR
- Publication Type :
- Academic Journal
- Accession number :
- 233298