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Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.
Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.
- Source :
-
British journal of cancer [Br J Cancer] 2013 Feb 05; Vol. 108 (2), pp. 271-7. Date of Electronic Publication: 2013 Jan 17. - Publication Year :
- 2013
-
Abstract
- Background: Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.<br />Methods: Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.<br />Results: In univariate analysis (n=293), the hazard ratio (HR) (95% confidence intervals) for dichotomous Ki-67 (≤ 10%, >10%) was 3.42 (1.76, 6.62) χ(2) (1 df)=9.8, P=0.002. In multivariate analysis, Ki-67 added significant predictive information to that provided by Gleason score and prostate-specific antigen (HR=2.78 (1.42, 5.46), χ(2) (1 df)=7.0, P=0.008).<br />Conclusion: The IHC Ki-67 scoring on prostate needle biopsies is practicable and yielded significant prognostic information. It was less informative than in the previous TURP cohort where tumour samples were larger and more comprehensive, but in more contemporary cohorts with larger numbers of biopsies per patient, Ki-67 may prove a more powerful biomarker.
- Subjects :
- Aged
Biomarkers, Tumor analysis
Biopsy, Needle
Cell Proliferation
Cohort Studies
Humans
Male
Neoplasm Grading
Prognosis
Prostate-Specific Antigen analysis
Prostatic Neoplasms metabolism
Prostatic Neoplasms pathology
Ki-67 Antigen analysis
Prostatic Neoplasms diagnosis
Prostatic Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 108
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23329234
- Full Text :
- https://doi.org/10.1038/bjc.2012.598